Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005383)
Formula
CYP2D6 ...
SVG example
Oxidationn
Reactant Linalool Product 8-hydroxy-linalool
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 111A2 (cyp111) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005385 Linalool 6,7-Epoxy-linalool Unclear Linalool [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005384 8-hydroxy-linalool 8-carboxy-linalool Oxidation - Oxidationn Linalool [2], [1], [3]
References
1 Study on the cytochrome P450-mediated oxidative metabolism of the terpene alcohol linalool: indication of biological epoxidation
2 A cytochrome P450 class I electron transfer system from Novosphingobium aromaticivorans. Appl Microbiol Biotechnol. 2010 Mar;86(1):163-75.
3 Metabolism of geraniol and linalool in the rat and effects on liver and lung microsomal enzymes

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