Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005479)
Formula
SVG example
Hydrolyzationn
Reactant Finerenone M1 Metabolite Product Finerenone M2 Metabolite
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005478 Finerenone Finerenone M1 Metabolite Other reaction - Aromatization Finerenone [1], [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005480 Finerenone M2 Metabolite Finerenone M3 Metabolite Oxidation - Oxidationn Finerenone [4]
References
1 Biotransformation of Finerenone, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, in Dogs, Rats, and Humans, In Vivo and In Vitro
2 Aldosterone and Mineralocorticoid Receptor Signaling as Determinants of Cardiovascular and Renal Injury: From Hans Selye to the Present
3 Results From Drug-Drug Interaction Studies In Vitro and In Vivo Investigating the Inhibitory Effect of Finerenone on the Drug Transporters BCRP, OATP1B1, and OATP1B3
4 DrugBank(Pharmacology-Metabolism):Finerenone

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