Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005486)
Formula
SVG example
Demethylation
Reactant Finerenone Product Finerenone M10 Metabolite
Reactant Info Product Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005478 Finerenone Finerenone M1 Metabolite Other reaction - Aromatization Finerenone [1], [2], [3]
MR005484 Finerenone Finerenone M13 Metabolite Oxidation - O-deethylation Finerenone [1], [2]
MR005485 Finerenone Finerenone M14 Metabolite Unclear Finerenone [1], [2], [3]
MR005481 Finerenone Finerenone M4 Metabolite Oxidation - Epoxidation; hydroxylation Finerenone [1], [3]
MR005487 Finerenone Finerenone M7 Metabolite Unclear Finerenone [1]
MR005488 Finerenone Finerenone M9 Metabolite Unclear Finerenone [1]
References
1 Biotransformation of Finerenone, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, in Dogs, Rats, and Humans, In Vivo and In Vitro
2 Aldosterone and Mineralocorticoid Receptor Signaling as Determinants of Cardiovascular and Renal Injury: From Hans Selye to the Present
3 Results From Drug-Drug Interaction Studies In Vitro and In Vivo Investigating the Inhibitory Effect of Finerenone on the Drug Transporters BCRP, OATP1B1, and OATP1B3

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