Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005481)
Formula
CYP3A4 ...
SVG example
Epoxidation; hydroxylation
Reactant Finerenone Product Finerenone M4 Metabolite
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - Epoxidation; hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005478 Finerenone Finerenone M1 Metabolite Other reaction - Aromatization Finerenone [1], [2], [3]
MR005486 Finerenone Finerenone M10 Metabolite Oxidation - Demethylation Finerenone [1]
MR005484 Finerenone Finerenone M13 Metabolite Oxidation - O-deethylation Finerenone [1], [2]
MR005485 Finerenone Finerenone M14 Metabolite Unclear Finerenone [1], [2], [3]
MR005487 Finerenone Finerenone M7 Metabolite Unclear Finerenone [1]
MR005488 Finerenone Finerenone M9 Metabolite Unclear Finerenone [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005482 Finerenone M4 Metabolite Finerenone M5 Metabolite Oxidation - Hydrolyzationn Finerenone [4]
References
1 Biotransformation of Finerenone, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, in Dogs, Rats, and Humans, In Vivo and In Vitro
2 Aldosterone and Mineralocorticoid Receptor Signaling as Determinants of Cardiovascular and Renal Injury: From Hans Selye to the Present
3 Results From Drug-Drug Interaction Studies In Vitro and In Vivo Investigating the Inhibitory Effect of Finerenone on the Drug Transporters BCRP, OATP1B1, and OATP1B3
4 DrugBank(Pharmacology-Metabolism):Finerenone

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