Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005494)
Formula
SVG example
Reactant Temsavir Product Fostemsavir M28
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005490 Fostemsavir Temsavir Hydrolysis - Hydrolysis Fostemsavir [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005509 Temsavir BMS-646915 Unclear Fostemsavir [1]
MR005508 Temsavir BMS-930644 Oxidation - N-dealkylation Fostemsavir [1]
MR005506 Temsavir Fostemsavir M18 Oxidation - Mono-oxidation Fostemsavir [1]
MR005512 Temsavir Fostemsavir M19 Unclear Fostemsavir [1]
MR005497 Temsavir Fostemsavir M20 Unclear Fostemsavir [1]
MR005491 Temsavir Fostemsavir M27 Oxidation - Mono-oxidation Fostemsavir [1]
MR005501 Temsavir Fostemsavir M4 Hydrolysis - Amide hydrolysis Fostemsavir [1]
MR005511 Temsavir Fostemsavir M6 Unclear Fostemsavir [1]
MR005510 Temsavir Fostemsavir M8 Unclear Fostemsavir [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005495 Fostemsavir M28 Fostemsavir M13 Unclear Fostemsavir [1]
References
1 Pharmacokinetics, metabolism and excretion of radiolabeled fostemsavir administered with or without ritonavir in healthy male subjects

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