Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005610)
Formula Reactant Selumetinib Product Selumetinib M8 (N-desmethyl selumetinib)
Reactant Info Product Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005614 Selumetinib Selumetinib M14 (AZ12791138) Unclear Selumetinib [1]
MR005625 Selumetinib Selumetinib M15 (AZ13326637) Hydrolysis - Amide hydrolysis Selumetinib [1]
MR005626 Selumetinib Selumetinib M4 (glucuronidated selumetinib) Conjugation - Glucuronidation Selumetinib [1]
MR005627 Selumetinib Selumetinib M7 (glucuronidated selumetinib) Conjugation - Glucuronidation Selumetinib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005623 Selumetinib M8 (N-desmethyl selumetinib) Selumetinib M11 (N-demethylated carboxylic acid selumetinib metabolite) Oxidation - Oxidationn Selumetinib [1]
MR005611 Selumetinib M8 (N-desmethyl selumetinib) Selumetinib M12 (Primary amide, N-demethylated selumetinib metabolite) Other reaction - Elimination Selumetinib [1]
MR005622 Selumetinib M8 (N-desmethyl selumetinib) Selumetinib M3 (glucuronidated N-desmethyl selumetinib) Conjugation - Glucuronidation Selumetinib [1]
MR005621 Selumetinib M8 (N-desmethyl selumetinib) Selumetinib M5 (glucuronidated N-desmethyl selumetinib) Conjugation - Glucuronidation Selumetinib [1]
References
1 Metabolism, Excretion, and Pharmacokinetics of Selumetinib, an MEK1/2 inhibitor, in Healthy Adult Male Subjects

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