General Information of This Metabolic Reaction (MR) (ID: MR005626)
Formula Reactant Selumetinib Product Selumetinib M4 (glucuronidated selumetinib)
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005614 Selumetinib Selumetinib M14 (AZ12791138) Unclear Selumetinib [1]
MR005625 Selumetinib Selumetinib M15 (AZ13326637) Hydrolysis - Amide hydrolysis Selumetinib [1]
MR005627 Selumetinib Selumetinib M7 (glucuronidated selumetinib) Conjugation - Glucuronidation Selumetinib [1]
MR005610 Selumetinib Selumetinib M8 (N-desmethyl selumetinib) Oxidation - N-demethylation Selumetinib [1]
References
1 Metabolism, Excretion, and Pharmacokinetics of Selumetinib, an MEK1/2 inhibitor, in Healthy Adult Male Subjects

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