General Information of This Metabolic Reaction (MR) (ID: MR005620)
Formula Reactant Selumetinib M12 (Primary amide, N-demethylated selumetinib metabolite) Product Selumetinib M9 (ribose conjugated selumetinib metabolite)
Reactant Info Product Info
Metabolic Type Conjugation - Ribose conjugation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005615 Selumetinib M14 (AZ12791138) Selumetinib M12 (Primary amide, N-demethylated selumetinib metabolite) Other reaction - Elimination Selumetinib [1]
MR005611 Selumetinib M8 (N-desmethyl selumetinib) Selumetinib M12 (Primary amide, N-demethylated selumetinib metabolite) Other reaction - Elimination Selumetinib [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005612 Selumetinib M12 (Primary amide, N-demethylated selumetinib metabolite) Selumetinib M10 selumetinib metabolite Oxidation - Oxidationn Selumetinib [1]
MR005619 Selumetinib M12 (Primary amide, N-demethylated selumetinib metabolite) Selumetinib M13 (Primary amide, N-demethylated, mono-oxidized selumetinib metabolite) Oxidation - Oxidationn Selumetinib [1]
References
1 Metabolism, Excretion, and Pharmacokinetics of Selumetinib, an MEK1/2 inhibitor, in Healthy Adult Male Subjects

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