Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005612)
Formula Reactant Selumetinib M12 (Primary amide, N-demethylated selumetinib metabolite) Product Selumetinib M10 selumetinib metabolite
Reactant Info Product Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005615 Selumetinib M14 (AZ12791138) Selumetinib M12 (Primary amide, N-demethylated selumetinib metabolite) Other reaction - Elimination Selumetinib [1]
MR005611 Selumetinib M8 (N-desmethyl selumetinib) Selumetinib M12 (Primary amide, N-demethylated selumetinib metabolite) Other reaction - Elimination Selumetinib [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005619 Selumetinib M12 (Primary amide, N-demethylated selumetinib metabolite) Selumetinib M13 (Primary amide, N-demethylated, mono-oxidized selumetinib metabolite) Oxidation - Oxidationn Selumetinib [1]
MR005620 Selumetinib M12 (Primary amide, N-demethylated selumetinib metabolite) Selumetinib M9 (ribose conjugated selumetinib metabolite) Conjugation - Ribose conjugation Selumetinib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005613 Selumetinib M10 selumetinib metabolite Selumetinib M1 selumetinib metabolite Oxidation - Oxidationn Selumetinib [1]
References
1 Metabolism, Excretion, and Pharmacokinetics of Selumetinib, an MEK1/2 inhibitor, in Healthy Adult Male Subjects

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