Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005642)
Formula
CYP3A4 ...
SVG example
N-demethylation
Reactant Venlafaxine hydrochloride Product N-Desmethylvenlafaxine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005637 Venlafaxine hydrochloride Desvenlafaxine Oxidation - O-demethylation Venlafaxine hydrochloride [1], [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005643 N-Desmethylvenlafaxine N,O-Didesmethylvenlafaxine Oxidation - O-demethylation Venlafaxine hydrochloride [1], [2], [3]
References
1 O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants. Neuropsychopharmacology. 1999 May;20(5):480-90.
2 Venlafaxine oxidation in vitro is catalysed by CYP2D6. Br J Clin Pharmacol. 1996 Feb;41(2):149-56.
3 Comparison of the pharmacokinetics of venlafaxine extended release and desvenlafaxine in extensive and poor cytochrome P450 2D6 metabolizers

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