Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005644)
Formula
SVG example
N-dealkylation
Reactant Verapamil hydrochloride Product Verapamil metabolite D-617
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C18 (CYP2C18) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005647 Verapamil hydrochloride Norverapamil Oxidation - N-demethylation Verapamil hydrochloride [1]
MR005650 Verapamil hydrochloride O-Desmethylverapamil (D-702) Oxidation - O-demethylation Verapamil hydrochloride [1]
MR005652 Verapamil hydrochloride O-Desmethylverapamil (D-703) Oxidation - O-demethylation Verapamil hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010526 Verapamil D-617 Unclear - Unclear Verapamil [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010528 D-617 D-620 Unclear - Unclear Verapamil [1]
MR010527 D-617 PR 25 Unclear - Unclear Verapamil [1]
MR005646 Verapamil metabolite D-617 Verapamil metabolite D-620 Oxidation - N-dealkylation Verapamil hydrochloride [1]
MR005645 Verapamil metabolite D-617 Verapamil metabolite PR-25 Oxidation - O-demethylation Verapamil hydrochloride [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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