Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005650)
Formula
CYP2C8 ...
SVG example
O-demethylation
Reactant Verapamil hydrochloride Product O-Desmethylverapamil (D-702)
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2C18 (CYP2C18) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - O-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005647 Verapamil hydrochloride Norverapamil Oxidation - N-demethylation Verapamil hydrochloride [1]
MR005652 Verapamil hydrochloride O-Desmethylverapamil (D-703) Oxidation - O-demethylation Verapamil hydrochloride [1]
MR005644 Verapamil hydrochloride Verapamil metabolite D-617 Oxidation - N-dealkylation Verapamil hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005651 O-Desmethylverapamil (D-702) Verapamil metabolite D-620 Oxidation - N-dealkylation Verapamil hydrochloride [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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