Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005656)
Formula
SVG example
Oxidationn
Reactant Vismodegib metabolite M3 Product Vismodegib metabolite M18
Reactant Info Product Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005655 Vismodegib Vismodegib metabolite M3 Oxidation - Hydrolyzationn Vismodegib [1], [2], [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005658 Vismodegib metabolite M3 Vismodegib metabolite M5 Conjugation - Glucuronidation Vismodegib [1], [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005661 Vismodegib Vismodegib metabolite M18 Oxidation - Oxidationn Vismodegib [1], [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005657 Vismodegib metabolite M18 Vismodegib metabolite M13 Oxidation - Oxidationn Vismodegib [1], [2], [3]
References
1 A single dose mass balance study of the Hedgehog pathway inhibitor vismodegib (GDC-0449) in humans using accelerator mass spectrometry
2 Absorption, distribution, metabolism, and excretion of [1?C]GDC-0449 (vismodegib), an orally active hedgehog pathway inhibitor, in rats and dogs: a unique metabolic pathway via pyridine ring opening
3 Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor

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