Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005658)
Formula
UGT
SVG example
Glucuronidation
Reactant Vismodegib metabolite M3 Product Vismodegib metabolite M5
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronyltransferase (UGT) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005655 Vismodegib Vismodegib metabolite M3 Oxidation - Hydrolyzationn Vismodegib [1], [2], [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005656 Vismodegib metabolite M3 Vismodegib metabolite M18 Oxidation - Oxidationn Vismodegib [1], [2], [3]
References
1 A single dose mass balance study of the Hedgehog pathway inhibitor vismodegib (GDC-0449) in humans using accelerator mass spectrometry
2 Absorption, distribution, metabolism, and excretion of [1?C]GDC-0449 (vismodegib), an orally active hedgehog pathway inhibitor, in rats and dogs: a unique metabolic pathway via pyridine ring opening
3 Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.