Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005662)
Formula
SVG example
Hydrolyzationn
Reactant Vismodegib Product Vismodegib metabolite M14
Reactant Info Product Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005659 Vismodegib Vismodegib metabolite M1 Unclear Vismodegib [1], [2], [3]
MR005661 Vismodegib Vismodegib metabolite M18 Oxidation - Oxidationn Vismodegib [1], [2]
MR005655 Vismodegib Vismodegib metabolite M3 Oxidation - Hydrolyzationn Vismodegib [1], [2], [3]
References
1 A single dose mass balance study of the Hedgehog pathway inhibitor vismodegib (GDC-0449) in humans using accelerator mass spectrometry
2 Absorption, distribution, metabolism, and excretion of [1?C]GDC-0449 (vismodegib), an orally active hedgehog pathway inhibitor, in rats and dogs: a unique metabolic pathway via pyridine ring opening
3 Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor

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