Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005659)
Formula
CYP3A4 ...
SVG example
Reactant Vismodegib Product Vismodegib metabolite M1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005662 Vismodegib Vismodegib metabolite M14 Oxidation - Hydrolyzationn Vismodegib [1], [2], [3]
MR005661 Vismodegib Vismodegib metabolite M18 Oxidation - Oxidationn Vismodegib [1], [2]
MR005655 Vismodegib Vismodegib metabolite M3 Oxidation - Hydrolyzationn Vismodegib [1], [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005660 Vismodegib metabolite M1 Vismodegib metabolite M4 Conjugation - Glucuronidation Vismodegib [1], [2], [3]
References
1 A single dose mass balance study of the Hedgehog pathway inhibitor vismodegib (GDC-0449) in humans using accelerator mass spectrometry
2 Absorption, distribution, metabolism, and excretion of [1?C]GDC-0449 (vismodegib), an orally active hedgehog pathway inhibitor, in rats and dogs: a unique metabolic pathway via pyridine ring opening
3 Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor

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