Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005665)
Formula
SVG example
Carbamate cleavage
Reactant Vorapaxar sulfate Product Amine metabolite M19
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Other reaction - Carbamate cleavage
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005663 Vorapaxar sulfate Vorapaxar sulfate metabolite M20 Oxidation - Hydrolyzationn Vorapaxar sulfate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005664 Vorapaxar sulfate metabolite M20 Amine metabolite M19 Unclear Vorapaxar sulfate [1]
References
1 Identification of human liver cytochrome P450 enzymes involved in the metabolism of SCH 530348 (Vorapaxar), a potent oral thrombin protease-activated receptor 1 antagonist

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