Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005669)
Formula
AOX1 ...
SVG example
Carboxylation
Reactant Vortioxetine Metabolite 1 Product LU-AA34443
Reactant Info Product Info
Metabolic Enzyme Aldehyde oxidase (AOX1) DME Info
Alcohol dehydrogenase class-I alpha (ADH1A) DME Info
Aldehyde dehydrogenase 1 (ALDH1) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Carboxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005668 Vortioxetine hydrobromide Vortioxetine Metabolite 1 Oxidation - Hydrolyzationn Vortioxetine hydrobromide [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005670 LU-AA34443 LU-AA34443 Glucuronide Metabolite Conjugation - Glucuronidation Vortioxetine hydrobromide [1], [2]
References
1 Identification of the cytochrome P450 and other enzymes involved in the in vitro oxidative metabolism of a novel antidepressant, Lu AA21004. Drug Metab Dispos. 2012 Jul;40(7):1357-65.
2 Vortioxetine: clinical pharmacokinetics and drug interactions. Clin Pharmacokinet. 2018 Jun;57(6):673-686.

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