Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005707)
Formula
SVG example
Reactant Alprostadil Product 13,14-dihydro-prostaglandin E1
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005706 Alprostadil 15-keto-13,14-dihydro-prostaglandin E1 Unclear Alprostadil [1], [2], [3], [4]
References
1 Pharmacokinetics of prostaglandin E1 and its main metabolites after intracavernous injection and short-term infusion of prostaglandin E1 in patients with erectile dysfunction
2 Synergism between PGE1-metabolites(13,14-dihydro-prostaglandin E1, 15-keto prostaglandin E1, 15-keto-13,14-dihydro-prostaglandin E1) and nitric oxide (NO) on platelet aggregation
3 Pharmacokinetics of vasoactive substances administered into the human corpus cavernosum
4 Effect of calcium ionophore A23187 on prostaglandin synthase type 2 and 15-hydroxy-prostaglandin dehydrogenase expression in human chorion trophoblast cells. Am J Obstet Gynecol. 2008 Nov;199(5):554.e1-8.

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