Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005724)
Formula
SVG example
Reactant Benzphetamine Product MethAmphetamine
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005728 Benzphetamine 2-nitroso-1-phenylpropane Unclear Benzphetamine [1]
MR005723 Benzphetamine Amphetamine Unclear Benzphetamine [2]
MR005727 Benzphetamine N-benzylethyl-alpha-phenylnitrone Unclear Benzphetamine [3]
MR005726 Benzphetamine N-hydroxynorbenzphetamine Unclear Benzphetamine [3]
MR005725 Benzphetamine Norbenzphetamine Unclear Benzphetamine [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007169 Famprofazone Methamphetamine Oxidation - N-dealkylation Famprofazone [4]
MR010841 Selegiline Methamphetamine Unclear - Unclear Selegiline [5]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007170 Methamphetamine Amphetamine Oxidation - N-demethylation Famprofazone [4]
MR010842 Methamphetamine Amphetamine Unclear - Unclear Selegiline [5]
MR007175 Methamphetamine Ephedrine Pseudoephedrine Oxidation - eta-hydroxylation Famprofazone [4]
MR007173 Methamphetamine p-Hydroxymethamphetamine Oxidation - p-hydroxylation Famprofazone [4]
References
1 Identification of the human and animal hepatic cytochromes P450 involved in clonazepam metabolism. Fundam Clin Pharmacol. 1993;7(2):69-75.
2 DrugBank(Pharmacology-Metabolism):Benzphetamine
3 Interaction of constitutive and phenobarbital-induced cytochrome P-450 isozymes during the sequential oxidation of benzphetamine. Explanation for the difference in benzphetamine-induced hydrogen peroxide production and 455-nm complex formation in microsomes from untreated and phenobarbital-treated rats
4 Identification of new urinary metabolites of famprofazone in humans
5 Physiologically Based Pharmacokinetic Modeling of Transdermal Selegiline and Its Metabolites for the Evaluation of Disposition Differences between Healthy and Special Populations

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