Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005762)
Formula
CYP3A4 ...
SVG example
Oxidationn
Reactant Doxapram hydrochloride Product AHR 5955
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005769 Doxapram hydrochloride AHR 0914 Unclear Doxapram hydrochloride [1], [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005763 AHR 5955 Doxapram metabolite H Unclear Doxapram hydrochloride [1], [2], [3]
References
1 Doxapram metabolism in human fetal hepatic organ culture
2 Identification of doxapram metabolites using high pressure ion exchange chromatography and mass spectroscopy
3 Population pharmacokinetics of doxapram in low-birth-weight Japanese infants with apnea. Eur J Pediatr. 2015 Apr;174(4):509-18.

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