Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005812)
Formula
CYP1A2 ...
SVG example
O-demethylation
Reactant GTS-21 Product 4-OH-GTS-21
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2E1 (CYP2E1) DME Info
Metabolic Type Oxidation - O-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005814 GTS-21 2-OH-GTS-21 Oxidation - O-demethylation GTS-21 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007483 4-OH-GTS-21 4-OH-GTS-21 glucuronide Conjugation - Glucuronidation GTS-21 [1]
MR005813 4-OH-GTS-21 4-OH-GTS-21-Glucuronide Conjugation - Glucuronidation GTS-21 [1]
References
1 Metabolism and disposition of GTS-21, a novel drug for Alzheimer's disease. Xenobiotica. 1999 Jul;29(7):747-62.

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