Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005867)
Formula
SVG example
Reactant Liothyronine Product Diiodothyronine
Reactant Info Product Info
Metabolic Enzyme Thyroxine 5-deiodinase (DIO3) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001577 Liothyronine Iodine Unclear Liothyronine [1]
MR001576 Liothyronine Tiratricol Oxidation - Deamination Liothyronine [1]
MR001575 Liothyronine Triiodothyronine sulfate Conjugation - Conjugation Liothyronine [2]
MR005868 Liothyronine 3, 3'-T2 Unclear L-thyroxine [3]
MR005866 Liothyronine Reverse triiodothyronine Unclear L-thyroxine [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001515 3,3',5-triiodothyronine Diiodothyronine Oxidation - Deiodination Levothyroxine sodium [4], [5], [6]
MR001516 Reverse triiodothyronine Diiodothyronine Oxidation - Deiodination Levothyroxine sodium [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001573 Diiodothyronine Monoiodothyronine Oxidation - Dehalogenation Liothyronine [2], [6], [7]
References
1 Ashley C. and Dunleavy A. (2014). The renal drug handbook. Caroline Ashley and Aileen Dunleavy.
2 DrugBank(Pharmacology-Metabolism)Liothyronine
3 Lipoatrophic diabetes: endocrine dysfunction and the response to control hypertriglyceridemia
4 LABEL:EVOTHYROXINE SODIUM injection
5 Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions. Front Pharmacol. 2023 Feb 8;14:1076254. doi: 10.3389/fphar.2023.1076254.
6 Role and Clinical Significance of Monocarboxylate Transporter 8 (MCT8) During Pregnancy. Reprod Sci. 2023 Jun;30(6):1758-1769. doi: 10.1007/s43032-022-01162-z.
7 Binding Characteristics of Thyroid Hormone Distributor Proteins to Thyroid Hormone Metabolites. Thyroid. 2022 Aug;32(8):990-999. doi: 10.1089/thy.2021.0588.

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