Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001516)
Formula
SVG example
Deiodination
Reactant Reverse triiodothyronine Product Diiodothyronine
Reactant Info Product Info
Metabolic Type Oxidation - Deiodination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001518 Levothyroxine sodium Reverse triiodothyronine Oxidation - Deiodination Levothyroxine sodium [1]
MR005866 Liothyronine Reverse triiodothyronine Unclear L-thyroxine [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001574 Liothyronine Diiodothyronine Oxidation - Dehalogenation Liothyronine [3]
MR001515 3,3',5-triiodothyronine Diiodothyronine Oxidation - Deiodination Levothyroxine sodium [4], [5], [6]
MR005867 Liothyronine Diiodothyronine Unclear L-thyroxine [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001573 Diiodothyronine Monoiodothyronine Oxidation - Dehalogenation Liothyronine [3], [6], [7]
References
1 Local activation and inactivation of thyroid hormones: the deiodinase family Mol Cell Endocrinol. 1999 May 25;151(1-2):103-19. doi: 10.1016/s0303-7207(99)00040-4.
2 Lipoatrophic diabetes: endocrine dysfunction and the response to control hypertriglyceridemia
3 DrugBank(Pharmacology-Metabolism)Liothyronine
4 LABEL:EVOTHYROXINE SODIUM injection
5 Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions. Front Pharmacol. 2023 Feb 8;14:1076254. doi: 10.3389/fphar.2023.1076254.
6 Role and Clinical Significance of Monocarboxylate Transporter 8 (MCT8) During Pregnancy. Reprod Sci. 2023 Jun;30(6):1758-1769. doi: 10.1007/s43032-022-01162-z.
7 Binding Characteristics of Thyroid Hormone Distributor Proteins to Thyroid Hormone Metabolites. Thyroid. 2022 Aug;32(8):990-999. doi: 10.1089/thy.2021.0588.

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