Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005916)
Formula
SVG example
Reactant CAM-2028 Product Norbenzydamine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005917 CAM-2028 Dealkylated metabolite Unclear CAM-2028 [1]
MR005915 CAM-2028 EBenzydamine N-oxid Unclear CAM-2028 [2], [3]
MR005918 CAM-2028 Hydroxy metabolite Unclear CAM-2028 [1]
MR005919 CAM-2028 N-oxide hydroxy metabolite Unclear CAM-2028 [1]
References
1 Pharmacology of benzydamine
2 Benzydamine N-oxygenation as an index for flavin-containing monooxygenase activity and benzydamine N-demethylation by cytochrome P450 enzymes in liver microsomes from rats, dogs, monkeys, and humans
3 Human plasma metabolic profiles of benzydamine, a flavin-containing monooxygenase probe substrate, simulated with pharmacokinetic data from control and humanized-liver mice

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.