General Information of This Metabolic Reaction (MR) (ID: MR005921)
Formula
Reactant CBL-954 Product 2-NHOH
Reactant Info Product Info
Metabolic Enzyme Nitroreductase NfsA (NfsA) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005922 CBL-954 4-NHOH Unclear CBL-954 [1]
MR005923 CBL-954 The hydroxylamine metabolite Unclear CBL-954 [2]
References
1 uvrB gene deletion enhances SOS chromotest sensitivity for nitroreductases that preferentially generate the 4-hydroxylamine metabolite of the anti-cancer prodrug CB1954
2 Bystander or no bystander for gene directed enzyme prodrug therapy

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