Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006027)
Formula Reactant Bedaquiline fumarate Product Bedaquiline fumarate Metabolite M2
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006024 Bedaquiline fumarate Bedaquiline fumarate Metabolite M5 Unclear Bedaquiline fumarate [1], [2]
MR006029 Bedaquiline fumarate N-desmethyl BDQ (M1) Oxidation - N-demethylation Bedaquiline fumarate [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006028 Bedaquiline fumarate Metabolite M2 Bedaquiline fumarate Metabolite M3 Oxidation - N-demethylation Bedaquiline fumarate [1], [2]
References
1 Bedaquiline metabolism: enzymes and novel metabolites. Drug Metab Dispos. 2014 May;42(5):863-6.
2 Effects of Rifamycin Coadministration on Bedaquiline Desmethylation in Healthy Adult Volunteers

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