General Information of This Metabolic Reaction (MR) (ID: MR006032)
Formula
SVG example
Reactant Belinostat Product 3-ASBA (3-Anilino-Sulfonyl Benzene Carboxylic Acid)
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006033 Belinostat Belinostat Acid Unclear Belinostat [1]
MR006031 Belinostat Belinostat Amide Unclear Belinostat [1]
MR006030 Belinostat Belinostat glucuronide Conjugation - Glucuronidation Belinostat [2], [3]
MR006034 Belinostat Methylated Belinostat Unclear Belinostat [1]
References
1 Pharmacokinetics, metabolism, and excretion of (14)C-labeled belinostat in patients with recurrent or progressive malignancies
2 Glucuronidation by UGT1A1 is the dominant pathway of the metabolic disposition of belinostat in liver cancer patients. PLoS One. 2013;8(1):e54522.
3 In vitro characterization of belinostat glucuronidation: demonstration of both UGT1A1 and UGT2B7 as the main contributing isozymes

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