Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006033)
Formula
CYP3A4 ...
SVG example
Reactant Belinostat Product Belinostat Acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2A6 (CYP2A6) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006032 Belinostat 3-ASBA (3-Anilino-Sulfonyl Benzene Carboxylic Acid) Unclear Belinostat [1]
MR006031 Belinostat Belinostat Amide Unclear Belinostat [1]
MR006030 Belinostat Belinostat glucuronide Conjugation - Glucuronidation Belinostat [2], [3]
MR006034 Belinostat Methylated Belinostat Unclear Belinostat [1]
References
1 Pharmacokinetics, metabolism, and excretion of (14)C-labeled belinostat in patients with recurrent or progressive malignancies
2 Glucuronidation by UGT1A1 is the dominant pathway of the metabolic disposition of belinostat in liver cancer patients. PLoS One. 2013;8(1):e54522.
3 In vitro characterization of belinostat glucuronidation: demonstration of both UGT1A1 and UGT2B7 as the main contributing isozymes

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