Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006042)
Formula	CYP3A4 Oxidationn
	Reactant	EMD 329989	Product	Sarizotan metabolite M362
	Reactant	Reactant Info	Product	Product Info
Metabolic Enzyme	Cytochrome P450 3A4 (CYP3A4)				DME Info
Metabolic Type	Oxidation - Oxidationn

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR006041	EMD-128130	EMD 329989	Oxidation - Hydrolyzationn	EMD-128130	[1]

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR006043	EMD 329989	Sarizotan metabolite M203	Unclear	EMD-128130	[1]

Other MR(s) Related to The Product of This MR

Other MR(s) That Metabolize The Produtc of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR006044	Sarizotan metabolite M362	Sarizotan metabolite M203	Unclear	EMD-128130	[1]

References
1	In vitro characterization of sarizotan metabolism: hepatic clearance, identification and characterization of metabolites, drug-metabolizing enzyme identification, and evaluation of cytochrome p450 inhibition. Drug Metab Dispos. 2010 Jun;38(6):905-16.

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