Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006114)
Formula
SVG example
Glucuronidation; hydroxylation
Reactant GEA-6414 Product N-(2-methyl-3-chloro-4-hydroxyphenyl)-anthranilic acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Multi-steps Reaction - Glucuronidation; hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006126 GEA-6414 Ether glucuronide ofN-(2-methyl-3-chloro-4-hydroxyphenyl)-anthranilic acid Conjugation - Glucuronidation GEA-6414 [1]
MR006124 GEA-6414 Glucuronide form of tolfenamic acid Conjugation - Glucuronidation GEA-6414 [1]
MR006119 GEA-6414 N-(2-hydroxymethyl-3-chlorophenyl)-anthranilic acid Multi-steps Reaction - Glucuronidation; hydroxylation GEA-6414 [1]
MR006127 GEA-6414 N-(2-methyl-3-chloro-5-hydroxyphenyl)-anthranilic acid Conjugation - O-glucuronidation GEA-6414 [1]
MR006117 GEA-6414 N-(2-methyl-3-chloro-5-hydroxyphenyl)-anthranilic acid form 2 Multi-steps Reaction - Glucuronidation; hydroxylation GEA-6414 [1]
MR006128 GEA-6414 N-(2-methyl-3-chlorophenyl)-4-hydroxy-anthranilic acid Multi-steps Reaction - Glucuronidation; hydroxylation GEA-6414 [1]
MR006125 GEA-6414 N-(2-methyl-3-chlorophenyl)-5-hydroxy-anthranilic acid Multi-steps Reaction - Glucuronidation; hydroxylation GEA-6414 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006116 N-(2-methyl-3-chloro-4-hydroxyphenyl)-anthranilic acid N-(2-methyl-3-chloro-4-metoxyphenyl)-anthranilic acid Reduction - Dehalogenation GEA-6414 [1]
MR006115 N-(2-methyl-3-chloro-4-hydroxyphenyl)-anthranilic acid N-(2-methyl-4-hydroxyphenyl)-anthranilic acid Reduction - Dehalogenation GEA-6414 [1]
References
1 Purification and 1H NMR spectroscopic characterization of phase II metabolites of tolfenamic acid

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