Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006161)
Formula
SVG example
Phosphorylation
Reactant Tenofovir Monophosphate Product Tenofovir Diphosphate
Reactant Info Product Info
Metabolic Enzyme Nucleoside diphosphate kinase (NME4) DME Info
Metabolic Type Conjugation - Phosphorylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006160 Tenofovir disoproxil Tenofovir Monophosphate Multi-steps Reaction - Diester hydrolysis; phosphorylation Tenofovir disoproxil [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003115 Tenofovir Tenofovir diphosphate Other reaction - Phosphorylation Tenofovir alafenamide [2]
MR003117 Tenofovir Tenofovir diphosphate Other reaction - Phosphorylation Tenofovir disoproxil fumarate [2]
MR010854 TFV-MP TFV-DP Unclear - Unclear Tenofovir [3]
MR010852 Tenofovir(TFV) Tenofovir-DP Unclear - Unclear GS-7340 [3]
References
1 Tenofovir disoproxil fumarate: clinical pharmacology and pharmacokinetics
2 Bictegravir/Emtricitabine/Tenofovir Alafenamide: a review in HIV-1 infection. Drugs. 2018 Nov;78(17):1817-1828.
3 Implications of efficient hepatic delivery by tenofovir alafenamide (GS-7340) for hepatitis B virus therapy

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