Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010852)
Formula
SVG example
Unclear
Reactant Tenofovir(TFV) Product Tenofovir-DP
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003116 Tenofovir alafenamide Tenofovir Hydrolysis - Hydrolyzation Tenofovir alafenamide [1]
MR003118 Tenofovir disoproxil fumarate Tenofovir Hydrolysis - Hydrolyzation Tenofovir disoproxil fumarate [1]
MR010851 Ala-TFV Tenofovir(TFV) Unclear - Unclear GS-7340 [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003115 Tenofovir Tenofovir diphosphate Other reaction - Phosphorylation Tenofovir alafenamide [1]
MR003117 Tenofovir Tenofovir diphosphate Other reaction - Phosphorylation Tenofovir disoproxil fumarate [1]
MR006161 Tenofovir Monophosphate Tenofovir Diphosphate Conjugation - Phosphorylation Tenofovir disoproxil [4]
MR010854 TFV-MP TFV-DP Unclear - Unclear Tenofovir [2]
References
1 Bictegravir/Emtricitabine/Tenofovir Alafenamide: a review in HIV-1 infection. Drugs. 2018 Nov;78(17):1817-1828.
2 Implications of efficient hepatic delivery by tenofovir alafenamide (GS-7340) for hepatitis B virus therapy
3 Tenofovir alafenamide in the treatment of chronic hepatitis B virus infection: rationale and clinical trial evidence
4 Tenofovir disoproxil fumarate: clinical pharmacology and pharmacokinetics

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