Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006183)
Formula
SVG example
Hydrolyzationn
Reactant Tibolone Product 3beta-OH-tibolone
Reactant Info Product Info
Metabolic Enzyme 3-hydroxysteriod dehydrogenase (3HSD) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006187 Tibolone 3alpha-OH-tibolone Oxidation - Hydrolyzationn Tibolone [1], [2], [3]
MR006189 Tibolone Delta(4)-tibolone Unclear Tibolone [1], [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006184 3beta-OH-tibolone 3beta-sulfated-tibolone Conjugation - Sulfation Tibolone [1], [2], [3]
MR006185 3beta-OH-tibolone Delta(4)-tibolone Unclear Tibolone [1]
References
1 Sulfation of tibolone and tibolone metabolites by expressed human cytosolic sulfotransferases. J Steroid Biochem Mol Biol. 2004 Apr;88(4-5):383-91.
2 Sulfation of tibolone metabolites by human postmenopausal liver and small intestinal sulfotransferases (SULTs). Steroids. 2006 May;71(5):343-51.
3 Antioxidant effect of the active metabolites of tibolone

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