Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006197)
Formula
SVG example
Glucuronidation
Reactant Tranilast Product Tranilast glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006194 Tranilast 4-demethyltranilast Oxidation - 4-demethylation Tranilast [1], [2]
MR006198 Tranilast Tranilast metabolite N-4 Oxidation - Demethylation Tranilast [2]
References
1 Glucuronidation of antiallergic drug, Tranilast: identification of human UDP-glucuronosyltransferase isoforms and effect of its phase I metabolite. Drug Metab Dispos. 2007 Apr;35(4):583-9.
2 Simultaneous determination of tranilast and metabolites in plasma and urine using high-performance liquid chromatography

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.