Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006194)
Formula
SVG example
4-demethylation
Reactant Tranilast Product 4-demethyltranilast
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - 4-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006197 Tranilast Tranilast glucuronide Conjugation - Glucuronidation Tranilast [1], [2]
MR006198 Tranilast Tranilast metabolite N-4 Oxidation - Demethylation Tranilast [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006196 4-demethyltranilast Tranilast metabolite N-3-G Conjugation - Glucuronidation Tranilast [1], [2]
MR006195 4-demethyltranilast Tranilast metabolite N-3-S Unclear Tranilast [1], [2]
References
1 Glucuronidation of antiallergic drug, Tranilast: identification of human UDP-glucuronosyltransferase isoforms and effect of its phase I metabolite. Drug Metab Dispos. 2007 Apr;35(4):583-9.
2 Simultaneous determination of tranilast and metabolites in plasma and urine using high-performance liquid chromatography

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.