Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006447)
Formula
CYP1A2 ...
SVG example
N7-demethylation
Reactant SC-15090 Product 7-MX
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2E1 (CYP2E1) DME Info
Metabolic Type Oxidation - N7-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006451 SC-15090 3,7-DAU Oxidation - 3-O-demethylation SC-15090 [1]
MR006450 SC-15090 3,7-DMU Oxidation - N7-demethylation SC-15090 [2]
MR006449 SC-15090 3-MX Oxidation - N3-demethylation SC-15090 [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006448 7-MX 7-MU Oxidation - Oxidationn SC-15090 [2]
References
1 Pharmacokinetics of novel atrial-selective antiarrhythmic agent vernakalant hydrochloride injection (RSD1235): influence of CYP2D6 expression and other factors. J Clin Pharmacol. 2009 Jan;49(1):17-29.
2 Cytochrome P450 isoform selectivity in human hepatic theobromine metabolism. Br J Clin Pharmacol. 1999 Mar;47(3):299-305.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.