Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006529)
Formula
SVG example
N-demethylation
Reactant Clarithromycin Product N-desmethylclarithromycin
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006528 Clarithromycin 14-hydroxyclarithromycin Oxidation - Hydrolyzationn Clarithromycin [1]
MR006531 Clarithromycin Cladinose Hydrolysis - Hydrolysis Clarithromycin [2]
MR006530 Clarithromycin Decladinose Clarithromycin Hydrolysis - Hydrolysis Clarithromycin [2]
References
1 Aquatic toxicity of the macrolide antibiotic clarithromycin and its metabolites
2 Quantification of clarithromycin, its 14-hydroxy and decladinose metabolites in rat plasma, gastric juice and gastric tissue using high-performance liquid chromatography with electrochemical detection

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