Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006589)
Formula Reactant Clonidine Product 4,5-dehydroclonidine
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006588 Clonidine 2,6-dichlorophenylguanidine Unclear Clonidine [1]
MR006587 Clonidine 4-Hydroxyclonidine Oxidation - 4-hydroxylation Clonidine [2]
MR006590 Clonidine 4-oxoclonidine Unclear Clonidine [1]
References
1 The metabolism of N,N'-dimethylclonidine by rat liver microsomes [proceedings]
2 CYP2D6 mediates 4-hydroxylation of clonidine in vitro: implication for pregnancy-induced changes in clonidine clearance. Drug Metab Dispos. 2010 Sep;38(9):1393-6.

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