Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006593)
Formula
CES1 ...
SVG example
Reactant Clopidogrel bisulfate Product Clopidogrel carboxylic acid derivative
Reactant Info Product Info
Metabolic Enzyme Carboxylesterase 1 (CES1) DME Info
Carboxylesterase 2 (CES2) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006591 Clopidogrel bisulfate 2-Oxoclopidogrel Oxidation - Oxidationn Clopidogrel bisulfate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006594 Clopidogrel carboxylic acid derivative Clopidogrel acyl glucuronide Conjugation - Glucuronidation Clopidogrel bisulfate [2]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Physiologically Based Pharmacokinetic (PBPK) Modeling of Clopidogrel and Its Four Relevant Metabolites for CYP2B6, CYP2C8, CYP2C19, and CYP3A4 Drug-Drug-Gene Interaction Predictions

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