Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006687)
Formula
SVG example
Oxidationn
Reactant 11-Hydroxy-delta-9-THC Product 11-Nor-9-carboxy-delta-9-THC
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006686 Dronabinol 11-Hydroxy-delta-9-THC Oxidation - 11-hydroxylation Dronabinol [1], [2], [3], [4]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006689 11-Hydroxy-delta-9-THC 11-Hydroxy-delta-9-THC-glucuronide Conjugation - Glucuronidation Dronabinol [1]
MR006690 11-Hydroxy-delta-9-THC 8,11-Dihydroxy-delta-9-THC Oxidation - 8-hydroxylation Dronabinol [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006688 11-Nor-9-carboxy-delta-9-THC 11-nor-9-carboxy-delta-9-THC-glucuronide Conjugation - Glucuronidation Dronabinol [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 CYP2C-catalyzed delta9-tetrahydrocannabinol metabolism: kinetics, pharmacogenetics and interaction with phenytoin. Biochem Pharmacol. 2005 Oct 1;70(7):1096-103.
3 Characterization of human hepatic and extrahepatic UDP-glucuronosyltransferase enzymes involved in the metabolism of classic cannabinoids
4 Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions

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