Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006689)
Formula Reactant 11-Hydroxy-delta-9-THC Product 11-Hydroxy-delta-9-THC-glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 1A10 (UGT1A10) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006686 Dronabinol 11-Hydroxy-delta-9-THC Oxidation - 11-hydroxylation Dronabinol [1], [2], [3], [4]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006687 11-Hydroxy-delta-9-THC 11-Nor-9-carboxy-delta-9-THC Oxidation - Oxidationn Dronabinol [1]
MR006690 11-Hydroxy-delta-9-THC 8,11-Dihydroxy-delta-9-THC Oxidation - 8-hydroxylation Dronabinol [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 CYP2C-catalyzed delta9-tetrahydrocannabinol metabolism: kinetics, pharmacogenetics and interaction with phenytoin. Biochem Pharmacol. 2005 Oct 1;70(7):1096-103.
3 Characterization of human hepatic and extrahepatic UDP-glucuronosyltransferase enzymes involved in the metabolism of classic cannabinoids
4 Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions

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