Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006701)
Formula
CYP3A4 ...
SVG example
N-debutylation
Reactant Dronedarone hydrochloride Product N-debutyl-dronedarone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - N-debutylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006708 Dronedarone hydrochloride C-dealkyl-dronedarone Oxidation - Dealkylation Dronedarone hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006702 N-debutyl-dronedarone Deaminated N,N-didebutyl-dronedarone Multi-steps Reaction - Deamination; debutylation Dronedarone hydrochloride [2]
MR006704 N-debutyl-dronedarone Phenol-dronedarone Oxidation - O-dealkylation Dronedarone hydrochloride [2]
MR006707 N-debutyl-dronedarone N,N'-didebutyl-dronedarone Oxidation - Debutylation Dronedarone hydrochloride [2]
MR006706 N-debutyl-dronedarone Propanoic acid-dronedarone Oxidation - Oxidationn deamination Dronedarone hydrochloride [2]
References
1 Identification of metabolic pathways and enzyme systems involved in the in vitro human hepatic metabolism of dronedarone, a potent new oral antiarrhythmic drug. Pharmacol Res Perspect. 2014 Jun;2(3):e00044.
2 DrugBank(Pharmacology-Metabolism):Dronedarone hydrochloride

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