Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006763)
Formula
SVG example
Reactant Tofacitinib citrate Product Tofacitinib citrate metabolite M6
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006766 Tofacitinib citrate Tofacitinib citrate metabolite M1 Oxidation - Oxidationn Tofacitinib citrate [1]
MR006767 Tofacitinib citrate Tofacitinib citrate metabolite M2 Oxidation - Oxidationn Tofacitinib citrate [1]
MR006768 Tofacitinib citrate Tofacitinib citrate metabolite M3 Oxidation - Oxidationn Tofacitinib citrate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006764 Tofacitinib citrate metabolite M6 Tofacitinib citrate metabolite M4 Unclear Tofacitinib citrate [2]
MR006765 Tofacitinib citrate metabolite M6 Tofacitinib citrate metabolite M5 Unclear Tofacitinib citrate [2]
References
1 Metabolic Activation of Tofacitinib Mediated by Myeloperoxidase in Vitro
2 Tofacitinib Is a Mechanism-Based Inactivator of Cytochrome P450 3A4

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