Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006874)
Formula Reactant Entacapone cis-isomer Product 3,4-Dihydroxy-5-nitrobenzaldehyde
Reactant Info Product Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006872 Entacapone Entacapone cis-isomer Other reaction - Isomerization Entacapone [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006873 Entacapone cis-isomer Entacapone 3-o-glucuronide Conjugation - Glucuronidation Entacapone [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009384 Nitecapone DP1 Other reaction - Retro aldol condensation Nitecapone [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009385 DP1 DP2 Oxidation - Oxidation Nitecapone [3]
References
1 European?Medicines?Agency?(EMA),?Committee?for?Medicinal?Products?for?Human?Use?(CHMP
2 Kinetic characterization of the 1A subfamily of recombinant human UDP-glucuronosyltransferases. Drug Metab Dispos. 2005 Jul;33(7):1017-26.
3 The equine metabolism of the catechol-O-methyltransferase enzyme inhibitor nitecapone

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