Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006896)
Formula
SVG example
N-hydroxylation
Reactant Loperamide hydrochloride Product Loperamide oxide
Reactant Info Product Info
Metabolic Type Oxidation - N-hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006897 Loperamide hydrochloride Loperamide carbinolamide metabolite Oxidation - C-hydroxylation Loperamide hydrochloride [1]
MR006895 Loperamide hydrochloride N-demethyl loperamide Oxidation - N-demethylation Loperamide hydrochloride [1]
References
1 Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes. Eur J Clin Pharmacol. 2004 Oct;60(8):575-81.

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