Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006895)
Formula
CYP3A4 ...
SVG example
N-demethylation
Reactant Loperamide hydrochloride Product N-demethyl loperamide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006897 Loperamide hydrochloride Loperamide carbinolamide metabolite Oxidation - C-hydroxylation Loperamide hydrochloride [1]
MR006896 Loperamide hydrochloride Loperamide oxide Oxidation - N-hydroxylation Loperamide hydrochloride [1]
References
1 Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes. Eur J Clin Pharmacol. 2004 Oct;60(8):575-81.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.