Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006938)
Formula Reactant Aprocitentan Product Macitentan metabolite M2
Reactant Info Product Info
Metabolic Type Multi-steps Reaction - Hydrolysis; hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006939 Aprocitentan Macitentan metabolite M1 Conjugation - Glycosylation Macitentan [1]
MR006940 Aprocitentan Macitentan metabolite M3 Hydrolysis - Hydrolysis Macitentan [1]
References
1 Clinical pharmacokinetics and pharmacodynamics of the endothelin receptor antagonist macitentan

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