Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006940)
Formula	Hydrolysis
	Reactant	Aprocitentan	Product	Macitentan metabolite M3
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Hydrolysis - Hydrolysis

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR006939	Aprocitentan	Macitentan metabolite M1	Conjugation - Glycosylation	Macitentan	[1]
MR006938	Aprocitentan	Macitentan metabolite M2	Multi-steps Reaction - Hydrolysis; hydroxylation	Macitentan	[1]

Other MR(s) Related to The Product of This MR

Other MR(s) That Produce The Product of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR006941	Macitentan	Macitentan metabolite M3	Hydrolysis - Hydrolysis	Macitentan	[1]

References
1	Clinical pharmacokinetics and pharmacodynamics of the endothelin receptor antagonist macitentan

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