Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007048)
Formula
SVG example
O-methylation
Reactant Hydroxyestrone Product 2-Methoxyestrone
Reactant Info Product Info
Metabolic Enzyme Catechol O-methyltransferase (COMT) DME Info
Metabolic Type Conjugation - O-methylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007047 Hydroxyestrone 2-hydroxyestrone 2-glucuronide Conjugation - O-glucuronidation Hydroxyestrone [1]
MR007049 Hydroxyestrone 3-O-methoxyestrone Conjugation - O-methylation Hydroxyestrone [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002693 2-hydroxyestrone 2-methoxyestrone Unclear Estrone [3]
MR013317 2-hydroxyestrone 2-methoxyestrone Unclear E-3A [4]
MR002640 2-hydroxyestrone 2-methoxyestrone Unclear Estradiol acetate [4]
MR002663 2-hydroxyestrone 2-methoxyestrone Unclear Estradiol cypionate [4]
MR002686 2-hydroxyestrone 2-methoxyestrone Unclear Estradiol valerate [4]
References
1 Structural and functional studies of UDP-glucuronosyltransferases. Drug Metab Rev. 1999 Nov;31(4):817-99.
2 BioTransformer: a comprehensive computational tool for small molecule metabolism prediction and metabolite identification
3 Evaluation of electrospray ionization and atmospheric pressure chemical ionization for simultaneous detection of estrone and its metabolites using high-performance liquid chromatography/tandem mass spectrometry J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Dec 1;860(1):49-56. doi: 10.1016/j.jchromb.2007.10.014.
4 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.